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4) included only adult subjects (age 18) with T2DM

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Lacking significant correlations between purine metabolites (UA and Xan) and 5-HIAA suggest that alterations in key serotonin pathways may both be modified by and contribute to oxidative stress via purine catabolism in FENNS

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In addition, by physically encapsulating urate deposits that cannot be cleared by individual macrophages, they contribute directly to granuloma formation and maintenance (160)